Nikos Spyropoulos (Greek: Νίκος Σπυρόπουλος, often transliterated Spiropoulos, born October 10, 1983), is a Greek professional football (soccer) player, currently playing for Panathinaikos FC in the Super League Greece.

He began his career with PAS Giannina in 2001 and after 3 seasons he caught the eye of Panionios. He was then signed to transfer to Panathinaikos, along with his teammates, Alexandros Tziolis and Evangelos Mantzios, but tested positive for an elevated T/E ratio and was initially suspended for two years. This was later attributed to natural causes, but his transfer was cancelled nevertheless. He returned to action one year later. He played for 3,5 years for Panionios with great success. He is regarded a major rising talent and is probably the best Greek left-side defender. His talent was initially ignored by Otto Rehhagel, but in 2007 the elector capped him, although he has not yet been in a starting lineup for the National team. Spyropoulos is left-footed and is distinguished by a combination of speed, strength, agility and endurance. On November 17, 2007 He made his National Team debut in the 5-0 Euro 2008 qualifyer defeat of Malta coming on for Vasilis Torosidis in the 46th minute. On January 2008 he moved to Panathinaikos for 2 million euros.